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The Risks of Manual Extraction

Are you still undertaking manual nucleic acid extraction?

Here are some issues to think about:

❌ Contamination risk
As with all manual pipetting workflows, manual purification bears the risk of carryover from sample to sample. Multichannel pipetting may reduce this risk, but it is only feasible for plate-based protocols. Even with multichannel pipetting, errors can occur when processing relatively large sample numbers over multiple rounds due to fatigue.

❌ Scaling issues 
Tube-format protocols limit the number of tubes lam members can process simultaneously in a centrifuge and other necessary equipment. 
Using smaller batches to process large sample numbers is a common workaround, but this is slow and requires a lot of manual effort. Thus, not a viable option for large-scale operations.

❌ Manual errors
In addition to sample carryover, manual protocols are prone to other errors. Picture this: you’ve labeled 36 sample tubes, and halfway through, the labels disintegrate when you sanitize your workspace. A simple scenario such as this can ruin an experiment and be challenging and expensive to fix. 

❌ Time constraints 
A short incubation step and a brief centrifuge spin leave a limited walk-away time per run, and processing samples in batches is even more time-consuming. By embedding purification into your lab’s workflow, you can help your staff spend their time on more value-driven activities. 

To learn more about our walk-away, budget-friendly extraction solutions, simply contact us at

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